Hepatic ischemia-reperfusion injury
Conditions
Interventions
Ciprofol pre-treatment group:General anesthesia was induced and maintained with conventional anesthetic drugs. Thirty minutes before reperfusion, 0.4 mg/kg of ciprofol was intravenously infused over 3
Control group:Receive only conventional anesthesia with placebo consistent with the appearance of cyclopofol, etc.
Sponsors
The Second Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: ASA classification of anesthesia: grades I-II; preoperative examination showed that the heart, lung and kidney functions were basically normal; met the indications for partial liver resection; received general anesthesia.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Those who have undergone repeated hepatic portal obstruction for a cumulative duration of more than 25 minutes; those with severe underlying diseases such as hypertension and diabetes; those who are extremely obese or emaciated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alanine aminotransferase;Aspartate aminotransferase;Superoxide dismutase;Malondialdehyde;Glutathione;Interleukin - 6 ;Interleukin - 10 ;Tumor Necrosis Factor - a; | — |
Countries
China
Contacts
Public ContactLi Guohua
The Second Affiliated Hospital of Shandong First Medical University
Outcome results
None listed