IHH is a rare genetic disorder characterized by the defect of hypothalamic GnRH neurons or impaired secretion of gonadotropins from the pituitary, leading to delayed puberty, hypogonadism, and low sex hormone levels
Conditions
Interventions
case group:none
control group:none
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
12 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Absence of Puberty: Males older than 12 years of age or >=18 years of age with no development of secondary sexual characteristics or increase in testicular volume; females with no development of secondary sexual characteristics or menarche by the age of 14; 2.Laboratory Findings: Laboratory results consistent with hypogonadotropic hypogonadism (low testosterone levels [<=100 ng/dL] and low or "inappropriately normal" gonadotropin [FSH and LH] levels); 3.Neuroimaging: Magnetic Resonance Imaging (MRI) showing no significant structural abnormalities in the hypothalamic-pituitary region; 4.Ethical Compliance: Written informed consent was obtained for the use of clinical data and samples for research purposes, or the medical records and samples were anonymized and complied with ethical;
Exclusion criteria
Exclusion criteria: 1.secondary causes (e.g., pituitary adenoma, systemic diseases, functional hypothalamic suppression);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinically confirmed IHH; | — |
Countries
China
Contacts
Public ContactLei Ye
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed