adolescent Major depressive disorder
Conditions
Interventions
Healthy control:Non-intervention
Sham group:Sham a-iTBS intervention
Active group:a-iTBS real intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for the patient group: (1) Age 12-18 years old, gender not limited; (2) Meet the diagnostic criteria for depressive disorder episodes in DSM-5; (3) CDRS >= 40 or HAMD-17 >=17; (4) Be capable of completing the scale assessment; (5) No physical therapy has been received in the past six months; (6) The patient and family members signed the informed consent form; 2.Inclusion criteria for the healthy group: (1) 12-18 years old; (2) In good physical health, with no depression, anxiety, or sleep problems; (3) The participant and family members signed the informed consent form; (4) Be capable of completing the scale assessment; (5) Capable of collecting relevant electrophysiological indicators.
Exclusion criteria
Exclusion criteria: 1. Meet other diagnostic criteria for mental disorders in DSM-5; 2. Have severe suicidal ideation or suicidal behavior; 3. Craniocerebral trauma or a history of coma; 4. Accompanied by organic brain or severe physical diseases (such as thyroid diseases, lupus erythematosus, diabetes, infections, major trauma, etc.); 5. Other contraindications for magnetic resonance imaging, such as having a pacemaker or metal objects that cannot be removed from the body; 6. Accompanied by a history of alcohol or drug dependence; 7. There has been a history of epileptic seizures or a family history of epilepsy; 8. The types and dosages of antidepressant drugs have been unstable in the past 15 days;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-item Hamilton Depression Scale (HAMD-17); | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores of other clinical symptom-related scales;Neuropsychological measurements related to cognitive behavior;electrophysiological and blood oxygenation indices; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed