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The influence of plasma separation adsorption versus whole blood adsorption on inflammatory factors and prognosis in patients with severe sepsis

The influence of plasma separation adsorption versus whole blood adsorption on inflammatory factors and prognosis in patients with severe sepsis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108066
Enrollment
Unknown
Registered
2025-08-25
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

control group:None
research group:None

Sponsors

The Affiliated Hospital of Jiangnan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. According to the latest Spsis3.0 definition, patients diagnosed with septic shock within = 100 pg/ml; 3.Age between 18 years and 80 years; 4.The patient or the patient's family has a full understanding of the purpose and significance of this trial, voluntarily participates in this clinical trial, and signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with compromised immune function: 1. Primary immunodeficiency diseases; 2. Patients who have received solid organ transplantation or bone marrow transplantation; 3. Those who are currently receiving corticosteroid treatment with a daily dose of >= 20 mg prednisone or an equivalent dose of >= 14 days; 4. Patients with malignant tumors undergoing chemotherapy; 5. Patients receiving other immunosuppressive drugs; 3. Patients with coagulation disorders, those with active bleeding, or those with uncontrollable acute major bleeding (within 24 hours); 4.Patients with malignant tumors and/or wasting diseases, those who cannot undergo lesion clearance (such as surgical patients who cannot undergo surgical treatment), or those with a low body weight (< 35 kg); 5.Platelet count lower than 20×10^9/L; 6. Patients who are expected to die within 48 hours; 7. Patients who have participated in or are currently participating in any clinical studies within the past month;

Design outcomes

Primary

MeasureTime frame
VIS score;interleukin-6;procalcitonin;hemameba;Hypersensitive C-reactive protein;Length of stay in the ICU;The duration of ventilator use;SOFA score;

Countries

China

Contacts

Public ContactYin Wang

The Affiliated Hospital of Jiangnan University

icu092005@163.com+86 150 6187 0796

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026