Visceral pain
Conditions
Interventions
Transcutaneous auricular vagus nerve stimulation group.:Electrical stimulation of the ear vagus nerve is performed in the auricular region.
Control group:Stimulate the non-vagal nerve areas such as the edge of the earlobe as a "false stimulation" control.
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. To undergo elective laparoscopic gastrointestinal surgery; 2. Age 18-70 years old, ASA classification I-III; 3. Clear consciousness, normal comprehension ability, and able to independently and clearly answer questions; 4. Fully understand and voluntarily participate in this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There were already other acute or chronic pains before the surgery; 2. Had been receiving opioid medication for a long time or had used any analgesics 48 hours before the surgery; 3. Patients who had received vagus nerve stimulation or acupuncture treatment within 1 month before the study; 4. Had a history of severe cardiovascular or cerebrovascular diseases, abnormal liver and kidney functions, or endocrine disorders before the surgery; 5. Had serious complications that required further monitoring in the ICU after the surgery; 6. Had a history of ear trauma, skin diseases, or other conditions that prevented the use of the stimulator; 7. Had cognitive impairments and speech expression defects, making it difficult to cooperate with the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Moderate-to-Severe Movement-Evoked Visceral Pain at 24 Hours Postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe visceral pain induced by moderate to intense exercise at 48 hours and 72 hours after the operation;Postoperative resting and exercise-induced visceral pain scores;Postoperative rest and exercise-induced incision pain scores;Remedy analgesia rate within 48 hours;Opioid consumption;Anxiety and depression scores;Postoperative recovery quality;The occurrence of postoperative adverse reactions;inflammatory factor(IL-1ßIL-6TNF-a);Stress hormones (CRH, CORT);Gut microbiota (intestinal microbial diversity, community composition, richness);Heart rate variablity; | — |
Countries
China
Contacts
Public ContactZiyang Chen
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed