Hypertensive surgery patients
Conditions
Interventions
Group C:Anesthesia induction using ciprofol
Group E:Anesthesia induction using etomidate
Sponsors
Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 65-80 years, regardless of gender, with a body mass index (BMI) of 18.5-25 kg/m^2; (2) Patients were awake before surgery, underwent elective surgery, and underwent general anesthesia with endotracheal intubation; (3) Patients were classified as American Society of Anesthesiologists (ASA) grade II-III and Mallampati airway grade I-II before surgery; (4) Patients had no severe heart, lung, brain, or other major organ diseases, and no significant abnormalities in liver and kidney function; (5) Patients were diagnosed with hypertension (grade 1 or above)
Exclusion criteria
Exclusion criteria: (1) Patients with high-degree atrioventricular block requiring pacemaker implantation or severe arrhythmia; (2) Patients who have long-term use of nonsteroidal anti-inflammatory drugs, narcotic analgesics or sedatives; (3) History of cerebral or thoracic/abdominal aortic aneurysm; (4) Allergy to any drug used in the study; (5) History of severe liver damage, i.e. Child-Pugh B or C; (6) Patients undergoing maintenance dialysis; (7) Congestive heart failure; (8) Untreated or unstable ischemic heart disease; (9) History of severe aortic valve or mitral valve disease; (10) Presence or anticipated presence of difficult airway;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of the difference between MAP and baseline in the first 10 minutes after induction;Incidence of hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| LOC and BIS less than 60 time;Number of patients receiving supplementary medication;Use of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactJinhui-Xu
Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)
Outcome results
None listed