Graves disease
Conditions
Interventions
Control Group:None
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Case group inclusion criteria: 1. newly diagnosed patients with Graves' disease, meeting the diagnostic criteria of the 2022 edition of the Chinese Guidelines for the Diagnosis and Treatment of Hyperthyroidism and Thyrotoxicosis due to Other Causes; 2. Age 18-70 years old at the time of enrollment, regardless of gender; 3. agree to participate in the study and sign an informed consent form; Inclusion criteria for the control group: 1. physical examination results suggesting that all systems of the body are basically normal; 2. Normal thyroid function, T3 1.3-3.1 nmol/L, T4 66-181 nmol/L, FT3 3.1-6.8 pmol/L, FT4 12-22 pmol/L, ultrasensitive TSH 0.27-4.2 mIU/L, and negative thyroid autoantibodies (TPOAb, TRAb, TgAb); 3. Age and gender matched with the GD group; 4. agreed to participate in the study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: Case group exclusion criteria: 1. history of autoimmune disease other than Graves' disease, family history; 2. History of thyroid-related diseases, family history; 3. have a history of malignant tumor; 4. In acute infectious phase with abnormal blood counts; 5. Have serious cardiovascular and cerebrovascular system diseases, liver diseases and kidney diseases; 6. Have a history of using immune agents and targeted drugs; 7. Pregnant or lactating women; Control group exclusion criteria: 1. Family history of autoimmune diseases; 2. History of using immune agents and targeted drugs; 3. Acute infections; 4. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genotype frequency;Allele frequency;ITK gene mRNA expression level;ITK protein expression level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Free Triiodothyronine;Free Thyroxine;Triiodothyronine;Thyroxine;Thyroid Stimulating Hormone;Thyroid Peroxidase Antibody;Thyroid Stimulating Hormone Receptor Antibody;Thyroglobulin Antibody; | — |
Countries
China
Contacts
Public ContactJunjie Zou
Shanghai Changzheng Hospital
Outcome results
None listed