Psoriasis
Conditions
Interventions
Experimental Group (Acitretin + Acupuncture Group):Take acitretin and apply topical moisturizing to the skin. The dosage of acitretin is 30mg/ day. After the symptoms are controlled, reduce the dosage
Control group (Acitretin + sham acupuncture group):On the basis of systemic administration of acitretin and topical skin moisturizing, A sham acupuncture therapy was adopted.
Sponsors
Chengdu Pidu District Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–70 years. 2.Diagnosed with psoriasis according to the clinical diagnostic criteria in Chinese Guidelines for the Diagnosis and Treatment of Psoriasis, with a course of plaque psoriasis = 6 months. 3.Baseline PASI score >= 10. 4.Signed informed consent form. 5.Dermatology Life Quality Index (DLQI) score > 10. 6.Previous ineffectiveness to topical medications.
Exclusion criteria
Exclusion criteria: 1.Severe infections. 2.Severe liver disease or clinical test results showing alanine transaminase (ALT)/aspartate transaminase (AST)/creatinine levels exceeding 1.5 times the upper limit of normal. 3.Alcoholic liver disease or other chronic liver diseases. 4.Renal failure. 5.Men and women planning to conceive within 3 months, pregnant women, and lactating women. 6.Patients with alcoholism. 7.Myelosuppression/hematological abnormalities (such as hypoplasia, leukopenia, thrombocytopenia, or severe anemia). 8.Patients with primary or secondary immunodeficiency. 9.Acute peptic ulcer. 10.Severe pulmonary insufficiency. 11.Patients allergic to acitretin or its related components. 12.Patients who have received systemic treatment within the past month. 13.Patients who have received biologic therapy within the past two months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PASI 50 response rate;Self-depression (PHQ-9) scale scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of days with ASI=50% within 16 weeks of follow-up);Self-rated anxiety (GAD-7) scale scores;PASI 75 response rate;Change in DLQI score(Dermatology Life Quality Index score change);Doctor/Patient overall evaluation (4-level Likert scale score);Duration of drug effectiveness(Days from discontinuation to recurrence);Improvement rate of lesion area;Assessment of adverse drug events; | — |
Countries
China
Contacts
Public ContactPeng Chang 'en
Chengdu Pidu District Hospital of Traditional Chinese Medicine
Outcome results
None listed