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The application effect of low-dose and low concentration remifentanil combined with body temperature protection in postoperative shivering of patients

A randomized, double-blind controlled study on postoperative shivering in patients receiving low-dose and low concentration remifentanil combined with postoperative thermal insulation therapy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500108029
Enrollment
Unknown
Registered
2025-08-22
Start date
2025-04-28
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative shivering

Interventions

Remifentanil group (RF group):All patients who experienced POS were insulated with a warm air heater set at 43 ? and given 10ug/ml remifentanil 0.5ug/kg. After about 5 seconds of static injection, all
Tramadol group (TM group):All patients who experienced POS were insulated with a warm air heater set at 43 ? and given tramadol 0.5mg/kg. After about 5 seconds of static stimulation, all patients star

Sponsors

Jiangsu Integrated Traditional Chinese and Western Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing general anesthesia 2. Patients who have severe chills (chills grade >=grade 2) in the anesthesia recovery unit (PACU) after extubation under general anesthesia, lasting more than 3 minutes 3. Patients between the ages of 18 and 70 and able to communicate normally to assist in collecting information 4. American Society of Anesthesiologists (ASA) class: I./II./III 5. Voluntarily sign the consent form and are willing to participate in this researcher

Exclusion criteria

Exclusion criteria: 1. Patients who have not signed the informed consent form for the clinical trial and refuse to participate in this study 2. Previous history of allergy to any of the drugs required to be used in the study 3. Patients who cannot communicate normally and cannot cooperate with information collection 4. Patients with severe cardiopulmonary, liver and kidney dysfunction 5. Patients with long-term heavy opioid use 6. Patients who are considered unsuitable to participate in the experiment by the investigator

Design outcomes

Primary

MeasureTime frame
Postoperative chills relief time;

Secondary

MeasureTime frame
Postoperative shivering relief rate;Postoperative shivering classification;Vital signs;Patient basic information;Occurrence rate of recurrent postoperative shivering;

Countries

China

Contacts

Public ContactHe Rong

Jiangsu Integrated Traditional Chinese and Western Medicine Hospital

496800257@qq.com+86 181 5135 7815

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026