Solar Lentigines
Conditions
Interventions
Group A:Laser+gel
Left face control group (general medical gel), right face test group (GM-CSF gel)
Group B:Laser+gel
Right face control group (general medical gel), left face test group (GM-CSF gel)
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 40–70 years (inclusive), regardless of gender; 2.Presence of characteristic sunspots on the face, each measuring >2mm × 2mm; 3.Concurrent facial pigmentation disorders such as melasma or freckles in addition to sunspots; 4.Fitzpatrick Skin Phototype (SPT) III to V; 5.No contraindications to GM-CSF therapy; 6.Non-occupational outdoor workers; 7.Demonstrated good compliance and ability to complete follow-up visits; 8.Voluntary participation in the study with signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding women; 2.Patients with other refractory pigmentary disorders on the face (e.g., vitiligo, Riehl's melanosis, etc.); 3.Presence of severe acne, eczema, allergic dermatitis, or other conditions in the treatment area, or factors significantly affecting efficacy evaluation (e.g., prominent scars, excessive hair growth, etc.); 4.Concurrent participation in other facial cosmetic clinical trials during the study period; 5.Unwillingness to discontinue all whitening and spot-lightening cosmetics during the study or inability to maintain proper sun protection measures; 6.Systemic diseases (including but not limited to liver or cardiovascular diseases, dyslipidemia, anemia, coagulation disorders, infectious diseases, psoriasis, diabetes, etc.); 7.History of excessive sun exposure within 1 month prior to study initiation; 8.Any treatment for sunspots (including chemical peels, laser therapy, intense pulsed light, medications, etc.) within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PIH; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change rate of brown spot grayscale;Patient satisfaction evaluation;Change rate of UV spot grayscale;Change rate of sunspot area; | — |
Countries
China
Contacts
Public ContactYao Min
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed