Primary premature ejaculation
Conditions
Interventions
SSRIS drug intervention group:rTMS sham stimulation Dapoxetine hydrochloride treatment
rTMS low-frequency SSRIS drug intervention group:rTMS low-frequency stimulation of dapoxetine hydrochloride treatment
rTMS high-frequency SSRIS drug intervention group:rTMS high-frequency stimulation of dapoxetine hydrochloride treatment
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-45 years old, male; (2) Meet the 2014 International Medical Association (ISSM) diagnostic criteria for primary premature ejaculation; (3) Adults who have a stable life with a sexual partner for at least 6 months, have sex at least 2 times a week, and remain stable during the study period; (4) Such situations occur in every sexual intercourse since the first sexual life; (5) No erectile dysfunction; (6) Premature ejaculation diagnostic scale score >= 9 points; (7) Have not received any other treatment for premature ejaculation in the past or present, or stop other treatments for at least 3 months; (8) Sign the informed consent form and receive monthly WeChat, telephone or outpatient follow-up and guidance.
Exclusion criteria
Exclusion criteria: (1) Secondary premature ejaculation, variable premature ejaculation, subjective premature ejaculation; (2) Patients with any history of serious medical diseases, mental illnesses, or neurological diseases; (3) Have a clear history of drug use or known diseases that can cause sexual dysfunction. (4) Left-handed patients (5) Use of serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and phosphodiester-5 inhibitors (PDE5-Is) or other drugs that may interfere with dapoxetine;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incubation period of vaginal ejaculation;Premature Ejaculation Diagnostic Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Erectile Function Assessment Questionnaire;Hamilton Depression Rating Scale;Hamilton Anxiety Scale;Pittsburgh Sleep Quality Assessment Scale; | — |
Countries
China
Contacts
Public ContactXiansheng Zhang
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed