Skip to content

The association between 25-hydroxyvitamin D levels and blood glucose levels with cervical spondylosis pain: Mendelian randomization and clinical study

The association between 25-hydroxyvitamin D levels and blood glucose levels with cervical spondylosis pain: Mendelian randomization and clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500108000
Enrollment
Unknown
Registered
2025-08-22
Start date
2025-08-25
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Spondylosis

Interventions

Healthy Control Group:None
Cervical spondylosis group:None

Sponsors

Hangzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: CS Group: 1. Clear diagnosis: Meet the clinical or imaging diagnostic criteria for cervical spondylosis (including cervical, radiculological, spinal or mixed types) (such as X-ray, MRI or CT showing degenerative changes in the cervical spine); 2. Presence of cervical spine related pain in the past 3 months, which can be assessed by numeric rating scale (NRS) (NRS>=3 points); 3. 18-80 years old (including 18 and 80 years old); 4. Able to provide fasting venous blood for blood glucose and 25(OH)D testing, and complete relevant scales/questionnaires; 5. Understand and be willing to participate in this clinical trial and provide signed informed consent. Healthy control group 1. No pain symptoms or cervical spondylosis related symptoms (limb numbness and weakness, etc.); 2. 18-80 years old (including 18 and 80 years old); 3. Able to provide fasting venous blood for blood glucose and 25(OH)D testing, and complete relevant scales/questionnaires; 4. Understand and be willing to participate in this clinical trial and provide signed informed consent.

Exclusion criteria

Exclusion criteria: CS Group: 1. Combined with serious systemic diseases: severe cardiovascular and cerebrovascular diseases, severe liver and kidney insufficiency, active malignant tumors or immune system diseases, etc.; 2. Use of vitamin D supplements or calcium supplements in the last 3 months; 3. Long-term use of glucocorticoids or anti-osteoporotic drugs; 4. Combined with other chronic pain diseases; 5. Pregnant or lactating women; 6. Recent (within 3 months) cervical spine surgery or interventional treatment; 7. Cognitive impairment or mental illness that prevents them from completing the scale/questionnaire assessments. Healthy control group 1. Combined with serious systemic diseases: severe cardiovascular and cerebrovascular diseases, severe liver and kidney insufficiency, active malignant tumors or immune system diseases, etc.; 2. Use of vitamin D supplements or calcium supplements in the last 3 months; 3. Long-term use of glucocorticoids or anti-osteoporotic drugs; 4. Pregnant or lactating women; 5. Recent (within 3 months) cervical spine surgery or interventional treatment; 6. Cognitive impairment or mental illness that prevents them from completing the scale/questionnaire assessment.

Design outcomes

Primary

MeasureTime frame
Numerical Rating Scale;

Countries

China

Contacts

Public ContactYu Liang

Hangzhou First People's Hospital

yuliang0601@zju.edu.cn+86 13957162972

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026