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Retrospective study of efficacy and safety of an initumab-based regimen as adjuvant therapy for early-stage HER2-positive breast cancer.

Retrospective study of efficacy and safety of an initumab-based regimen as adjuvant therapy for early-stage HER2-positive breast cancer.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500107999
Enrollment
Unknown
Registered
2025-08-22
Start date
2025-08-26
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Interventions

Observational Group:None

Sponsors

The Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Case detection-confirmed HER2-positive invasive breast cancer, consistent with adjuvant therapy indications; HER2-positive is defined as HER2 3+ by immunohistochemical staining (IHC) or positive by fluorescence in situ hybridization (FISH); 2. ECOG score 0-2; 3.>=4 cycles of enito-based regimen; consistent and complete data information available in the medical records system;

Exclusion criteria

Exclusion criteria: 1. Prior systemic treatment for any other malignancy; incompliant patients with psychiatric disorders or psychotropic substance abuse; 2. Patients with secondary malignant tumors; 3. Patients with poor compliance (2 non-tolerated unexplained discontinuations); 4. Clinical data were missing seriously, including general condition, laboratory examination results, imaging examination results and follow-up conditions, which were insufficient to evaluate the efficacy and adverse reactions of patients.

Design outcomes

Primary

MeasureTime frame
Disease-free survival;Recurrence rate;

Secondary

MeasureTime frame
Safety;Overall Survival;

Countries

China

Contacts

Public ContactHan Zhengxiang

The Affiliated Hospital of Xuzhou Medical University

cnhzxyq@163.com+86 180 5226 8612

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026