UC(ulcerative colitis)
Conditions
Interventions
Monotherapy with oral Mesalazine (0.8 g TID) group:Patients received mesalazine orally at a dose of 0.8 g 3 times daily. The duration of treatment is 12 weeks.
LHT enema (100 mL QD) monotherapy group:LHT was prepared by decocting a mixture of Salvia plebeia, Rubia cordifolia charcoal, Lithospermum erythrorhizon, Galla chinensis, and Pulsatilla chinensis to a
Combination regimen group:Patients received mesalazine orally at a dose of 0.8 g 3 times daily. And the nightly enema is left in place for 2 hours. The duration of treatment is 12 weeks.
Sponsors
Jiangyin Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-65 years; 2. Patients with ulcerative colitis in the rectosigmoid area; 3. Clinical symptoms Mayo score is 6-10 points.
Exclusion criteria
Exclusion criteria: 1. Other intestinal diseases (e.g., bacterial dysentery, intestinal tuberculosis, Crohn's disease); 2. Severe intestinal complications (e.g., intestinal perforation, obstruction, toxic megacolon, colorectal cancer); 3. Severe comorbidities, such as severe heart, liver, lung, or kidney disease; 4. Severe physical disability (e.g., blindness, deafness, muteness, intellectual disability, mental illness, or physical disability); 5. History of alcohol or drug abuse; 6. Participation in other concurrent clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mayo Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| UCEIS Score;Gebos Score;Immunohistochemical analysis of NLRP3/Caspase-1 and Nrf2/HO-1 and macrophage expressions;the levels of TNF-a, IL-18, and IL-1ß; | — |
Countries
China
Contacts
Public ContactMa Jiong
Jiangyin Hospital of Traditional Chinese Medicine
Outcome results
None listed