cutaneous lupus erythematosus
Conditions
Interventions
Gold Standard:Since the final clinical diagnosis based on the classification criteria requires a publicly recognized "gold standard," each case's information is summarized using a (uniformly designed
Index test:The proposed diagnostic index test is a set of classification criteria for various subtypes of cutaneous lupus erythematosus (CLE), including acute CLE (ACLE), subacute CLE (SCLE), discoid
Sponsors
Dermatology Hospital, Chinese Academy of Medical Sciences (Institute of Dermatology, Chinese Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Inclusion of lupus patients: Refer to the Asian Dermatological Association (ADA) guidelines for the diagnosis, treatment, and long-term monitoring of cutaneous lupus erythematosus (2021). Patients clinically diagnosed with any type of CLE, based on clinical manifestations and histopathological characteristics, are included. This includes acute cutaneous lupus erythematosus (ACLE), subacute cutaneous lupus erythematosus (SCLE), and chronic cutaneous lupus erythematosus (CCLE). ACLE can be subdivided into localized and generalized subtypes; SCLE can be subdivided into erythema multiforme-like and papulosquamous subtypes; CCLE can be subdivided into localized discoid lupus erythematosus (DLE), disseminated discoid lupus erythematosus (DDLE), verrucous lupus erythematosus (VLE), tumid lupus erythematosus (TLE), lupus erythematosus profundus (LEP), chilblain lupus erythematosus (CHLE), Blaschko linear lupus erythematosus (BLLE) and Bullous lupus erythematosus(BLE) ; 2.Inclusion of patients for differential diagnosis: Patients diagnosed with non-CLE conditions that need to be differentiated from CLE, ensuring that the control group matches the case group in basic characteristics such as age and gender. The specific diseases for differential diagnosis for each type of CLE patient are as follows (at least five diseases that are most easily confused with each subtype are selected). The inclusion criteria for each disease are based on internationally recognized diagnostic standards for complete clinical confirmation of the disease.
Exclusion criteria
Exclusion criteria: 1. The clinical data is incomplete, making it impossible to comprehensively assess the condition; 2. There is a coexistence of two or more CLE subtypes. Except for VLE and CHLE, which are two subtypes that rarely exist independently, and BLLE and BLE, which are two special CLE subtypes that commonly occur on the basis of a common CLE subtype, the coexistence of at most one other CLE subtype is allowed (the coexistence of two or more other CLE subtypes should be excluded). For cases reported in the literature and those in the previous sample database, the coexistence of other non-CLE diseases is not excluded. For example, patients with overlapping syndromes that meet the diagnostic criteria for CLE are allowed to be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| medical history, symptoms, and physical signs;Hematological laboratory tests;Histopathological features; | — |
Countries
China
Contacts
Public ContactQianjin Lu
Dermatology Hospital, Chinese Academy of Medical Sciences (Institute of Dermatology, Chinese Academy of Medical Sciences)
Outcome results
None listed