Gastrointestinal stromal tumor
Conditions
Interventions
Imatinib Neoadjuvant Therapy Group for Locally Advanced Gastric Gastrointestinal Stromal Tumors:None
Sponsors
Zhongshan Hospital, Fudan University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients pathologically diagnosed with gastric-origin gastrointestinal stromal tumors (GISTs); 2. Age between 18 and 75 years (inclusive); 3. Gastric GISTs larger than 10 cm, or larger than 5 cm located at anatomically challenging gastric sites, which are technically resectable but may compromise organ function; 4. Eastern Cooperative Oncology Group (ECOG) performance status <2 and American Society of Anesthesiologists (ASA) score <3; 5. No other severe comorbidities or conditions that could interfere with efficacy evaluation; 6. Written informed consent obtained from the patient or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients with severe comorbidities who are unable to tolerate surgery, such as significant cardiopulmonary diseases (e.g., NYHA class > II heart failure, pulmonary infection, moderate to severe COPD, chronic bronchitis), poorly controlled diabetes and/or renal insufficiency, severe hepatitis and/or liver dysfunction classified as Child-Pugh class C or symptomatic and difficult-to-correct class B, severe malnutrition, etc.; 2. Patients with severe psychiatric disorders; 3. Patients with a history of other malignancies within the past five years; 4. Patients previously treated with other tyrosine kinase inhibitors (TKIs); 5. Patients with disease-related complications such as bleeding, perforation, or obstruction; 6. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological complete response rate;Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrence-Free Survival;Overall Survival; | — |
Countries
China
Contacts
Public ContactShen Kuntang
Zhongshan Hospital, Fudan University School of Medicine
Outcome results
None listed