spinal cord injury
Conditions
Interventions
Experimental group:Subjects will undergo implantation surgery of a spinal test stimulator and epidural electrode
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–60 years (no gender restriction); 2.Clinically diagnosed with paraplegia after spinal cord injury; 3.Six months or more after spinal cord injury (spinal shock phase has passed, with no significant recovery or deterioration in sensory and motor functions); 4.Injury level: above the T12 vertebral level, with normal upper limb motor function; 5.Unable to stand or walk independently; 6.No brain diseases confirmed by cranial MRI examination; 7.Brain electrical decoding rate of >= 40% in task-attempt training for lower limb movement; 8.Able to cooperate with imaging examinations; 9.Having a strong willingness to rehabilitate and good family support; 10.Spinal cord injury graded as A, B, or C according to the American Spinal Injury Association (ASIA) Impairment Scale.
Exclusion criteria
Exclusion criteria: 1.Females who are pregnant; 2.Drug abuse or alcoholism; 3.Diseases restricting lower limb mobility: diseases causing limited hip joint movement such as developmental dysplasia of the hip, diabetic foot, severe osteoporosis, lower limb joint contracture deformity, spasm, fracture (progressive/resulting in deformation due to fracture), hospitalization for autonomic dysreflexia in the past 3 months, etc.; 4.Neurological diseases/injuries: craniocerebral injury, epilepsy, neurodegenerative diseases or neuropathy, severe anxiety and depression, suicidal tendencies; 5.Presence of surgical contraindications: infectious diseases, unstable angina pectoris, severe arrhythmia and other heart diseases; immune system diseases and major organ diseases; coagulation disorders and bleeding tendencies; ankylosing spondylitis, malignant tumors; spinal instability, spinal stenosis; 6.BMI >= 30.0 kg/m^2; 7.Those with cognitive impairment (MMSE 17 points); 8.Those unable to follow the research procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| American Spinal Injury Association (ASIA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Athworth;3-meter walking time;plantar pressure value;lower limb muscle volume;step length;Visual Analogue Scale (VAS);Sexual Health Inventory for Men (SHIM)/ Sexual Concerns Scale for Women (SCS – W);International Consultation on Incontinence Questionnaire-Short Form (ICI-Q-SF);intestinal function rating scale; | — |
Countries
Chnia
Contacts
Public ContactJing Ding
Zhongshan Hospital, Fudan University
Outcome results
None listed