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A Randomized Controlled Trial of Adjunctive rTMS for Anhedonia in Schizophrenia: Study Rationale and Protocol Design

A Randomized Controlled Trial of Adjunctive rTMS for Anhedonia in Schizophrenia: Study Rationale and Protocol Design

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107965
Enrollment
Unknown
Registered
2025-08-21
Start date
2025-08-21
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

active stimulation group:Transcranial magnetic stimulation of the dorsomedial prefrontal cortex
sham stimulation group:sham transcranial magnetic stimulation of the dorsomedial prefrontal cortex

Sponsors

Zigong mental health centre
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Participant inclusion criteria were age between 18 - 55 years, no change in medication in the past two months, no psychotherapy during trial period, right-handed, having normal vision or corrected to normal vision, and no prior experience with WCST.

Exclusion criteria

Exclusion criteria: Exclusion criteria were current substance abuse, personality disorders, mental retardation, color blindness, severe cardiovascular, hepatic, or renal disease, pregnancy or breastfeeding, presence of metal objects in the skull, and receiving electroconvulsive therapy within 3 months.

Design outcomes

Primary

MeasureTime frame
the Chinese version of Snaith-Hamilton Pleasure Scale;

Secondary

MeasureTime frame
Scale for Assessment of Negative Symptoms(SANS);the Temporal Experience of Pleasure Scale(TEPS);Changes of HBO2 and deoxyhemoglobin with near-infrared brain functional imaging;Wisconsin Card Test Correct Quantity;Wisconsin Card Test Error Quantity;Number of Wisconsin card test persistent errors;Number of non-persistent errors in the Wisconsin card test;Wisconsin card test total number of categories;The number of Wisconsin cards required to complete the first category;

Countries

China

Contacts

Public ContactWu Hao

Zigong mental health centre

1464799738@qq.com+86 136 9948 2593

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026