schizophrenia
Conditions
Interventions
active stimulation group:Receive rTMS intervention in the form of continuous 10-day, 3-times-per-day iTBS for at least 1 hour between each intervention. The stimulation site is L-DLPFC, with a stimula
sham stimulation group:We flipped the coil 180° to provide a false stimulus. The false coil can also generate a magnetic field, which participants can feel, but this magnetic field will not penetrate
Sponsors
Zigong mental health centre
Eligibility
Sex/Gender
All
Age
60 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; 2. Stable clinical status and taking antipsychotic medication: continuously taking a stable dose of antipsychotic medication for more than 4 weeks; 3. Age between 18 and 60 years; 4. MoCA score of 19-25, able to cooperate in completing the scale; 5. Right-handed.
Exclusion criteria
Exclusion criteria: 1. Presence of any significant neurological disorder; 2. Presence of mental retardation; 3. History of seizures or presence of epileptic activity on baseline electroencephalogram (EEG) (subject to evaluation by clinical EEG and epileptologist); 4. Alcohol or drug abuse within the last 3 months; 5. Depressive episodes or antidepressant treatment within the last 4 weeks; 6. History of electroconvulsive therapy (ECT); 7. Have a pacemaker, drug pump, cochlear implant, defibrillator, neurostimulator, or other metal device implanted in the body that is incompatible with rTMS; 8. Presence of severe damage to the skin surface in the area of cranial stimulation; 9. Being pregnant; 10. Presence of a serious physical illness; 11. Presence of severe positive symptoms that may interfere with the administration of cognitive tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The score of the Repeatable Battery for the Assessment of Neuropsychological Status; | — |
Secondary
| Measure | Time frame |
|---|---|
| The score of Positive and Negative Syndrome Scale;Changes of HBO2 and deoxyhemoglobin in near-infrared brain functional imaging; | — |
Countries
China
Contacts
Public ContactYuke He
Zigong mental health centre
Outcome results
None listed