postoperative delirium
Conditions
Sponsors
Ganzi Tibetan Autonomous Prefecture People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASAI~III level; 2. Age>=18 years old; 3. Resident residents of plateau areas; 4. Patients who plan to undergo knee replacement under general anesthesia; 5. Operation time 2-5 hours; 6.BMI<=28kg/m² ; 7. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative delirium; 2. Those with a history of insulin allergy or alcoholism; 3. Inability to communicate before surgery (coma, deep dementia or speech impairment); 4. Patients who are contraindicated to nasal administration (such as nasal defects or lesions); 5. Previous hypertension and diabetes; 6. Mini-mentalState Examination (MMSE) score (illiteracy< 17 points, primary school level <20 points, secondary school level (including technical secondary school) <24 points); 7. Severe cardiovascular and renal function diseases; 8. History of neurological diseases; 9. Preoperative history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 10. Severe visual and auditory impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POD incidence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Long term cognitive function;Pain score;interleukin-6;interleukin-1ß;Tumor Necrosis Factor-a;C-reactive protein;Monocyte chemoattractant protein-1; | — |
Countries
China
Contacts
Public ContactLuo Xiaoqin
Ganzi Tibetan Autonomous Prefecture People's Hospital
Outcome results
None listed