Langerhans Cell Histiocytosis
Conditions
Interventions
Control group:None
LCH patients:None
Sponsors
Beijing Childrens Hospital,Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.Healthy volunteers (Peripheral blood): (1) All of the indicatiors of blood routine and biochemical examinations were normal; (2) no more than 18 years old; (3) No previous diseases of the blood system, immune system or genetic diseases. (4) Remaining peripheral blood from blood routine and biochemical examinations in the Department of Clinical Laboratory Center. (5) Children or their parents signed the informed consent. 2.Healthy volunteers (cerebrospinal fluid): (1) no more than 18 years old; (2) The remaining cerebrospinal fluid from the cerebrospinal fluid biochemical re-examinations of children with viral encephalitis during the complete remission period. (3) All the indicators of the cerebrospinal fluid biochemical re-examinations were normal. (4)Children or their parents signed the informed consent. 3.LCH patients: (1) Pathologically diagnosed as LCH. (2) no more than 18 years old. (3) patients haven't received chemotherapy after the first diagnosis. (4) signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.Healthy volunteers (Peripheral blood and cerebrospinal fluid) : Children had suffered from hematological, immune system, hereditary, and central nervous system tumor diseases previously. 2.LCH patients: (1) Received chemotherapy (other than hormonal) after the first diagnosis; (2) Be allergic to the drugs used in the regimens. (3) Patients involved in other clinical studies at the same time. (4) Patients did‘t follow up the regimen plans due to personal reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Specific protein marker in cerebrospinal fluid and plasma of Langerhans cell histiocytosis children with the posterior pituitary involvement;Specific metabolic marker in cerebrospinal fluid and plasma of Langerhans cell histiocytosis children with the posterior pituitary involvement; | — |
Countries
China
Contacts
Public ContactNa Li
Beijing Childrens Hospital,Capital Medical University
Outcome results
None listed