colorectal cancer
Conditions
Interventions
Remazolam group(R group):Remazolam injection
Propofol group(P group):Propofol injection
Sevoflurane group(S group):Sevoflurane
Sponsors
The First People's Hospital of Neijiang
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1, 18<= age <=70 years old, gender is not limited; 2. Laparoscopic surgery for colorectal cancer; 3. ASA grade I-III; 4, BMI<=30kg/m^2; 5. Participate in the study voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Serious heart, brain, lung, liver and kidney diseases ; 2 .Patients with neuropsychiatric diseases (schizophrenia, mania, bipolar disorder, insanity, etc.) and long-term history of taking psychiatric drugs and cognitive dysfunction; 3. History of eye diseases such as glaucoma and eye infection; 4. History of eye surgery or craniocerebral surgery; 5. History of neck and cerebrovascular diseases; 6. Allergic or contraindicated to benzodiazepines, opioids, propofol, muscle pine and other drugs and their drug components; 7. Participated in drug clinical trials as a subject within the past 3 months; 8. Patients who are judged to have airway management difficulties (modified Mallampati level IV); 9. Other conditions that the investigator considers inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic Nerve Sheath Diameter/Eyeball Transverse Diameter (ONSD/ETD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum percentage change in ONSD/ETD from baseline;Regional cerebral oxygen saturation; | — |
Countries
China
Contacts
Public ContactHuang Hui
The First People's Hospital of Neijiang
Outcome results
None listed