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Study on High PEEP in the Treatment of Neonatal Respiratory Distress Syndrome

Study on High PEEP in the Treatment of Neonatal Respiratory Distress Syndrome

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107900
Enrollment
Unknown
Registered
2025-08-20
Start date
2025-05-15
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal Respiratory Distress Syndrome

Interventions

higher-PEEP group:PEEP initial setting at 7 cmH2O, gradually increased to 9 cmH2O over 2 hours (to avoid rapid lung inflation injury), adjusted between 8.5–11 cmH2O according to lung inflation confirm
control group:PEEP is adjustable within 6–8 cmH2O for >=24 hours.

Sponsors

The Affiliated Suqian Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) newborns at gestation age of 34+0 to 39+6 weeks; (2) NRDS diagnosed by chest radiography or lung ultrasound; (3) requirement of mechanical ventilation.

Exclusion criteria

Exclusion criteria: (1) chromosomal abnormalities; (2) congenital malformations affecting respiratory function; (3) pneumothorax occurring prior to mechanical ventilation; (4) missing of guardian informed consent.

Design outcomes

Secondary

MeasureTime frame
oxygenation index, OI;Highest PIP, FIO2, and respiratory rate;—

Primary

MeasureTime frame
the duration of mechanical ventilation (hour);Dose of pulmonary surfactant;—

Countries

China

Contacts

Public ContactTao Ning

The Affiliated Suqian Hospital of Xuzhou Medical University

ningtaocds@126.com+86 151 6129 3933

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026