Alzheimer's Disease
Conditions
Interventions
Group of chronic neurodegenerative diseases:NA
Group of Acute Neurodegenerative Diseases:NA
Sponsors
Zhengzhou Central Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for neurodegenerative diseases: 1. Age 50 to 90 years old, no gender restrictions; 2. Patients with neurodegenerative diseases that meet clinical diagnostic criteria; 3. Subsequent MRI results are required to assist in differential diagnosis; 4. Participants must fully understand the inclusion requirements and sign the informed consent. Inclusion criteria for healthy controls: 1. Age 50 to 90 years old, no gender restrictions; 2. Normal healthy individuals undergoing physical examinations; 3. Normal blood routine, blood biochemistry, urine routine, and infection indicators; 4. Participants must fully understand the inclusion requirements and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Participants under 50 years old or over 90 years old are excluded. 2. Participants who have undergone surgery, trauma or pregnancy within the past six months are excluded. 3. Participants with a history of stereotactic surgery on the head (including neuroablative procedures or deep brain stimulation) are excluded. 4. Participants with obvious mental disorders or severe cardiovascular comorbidities are excluded. 5. Participants whose peripheral blood samples show signs of coagulation or have been stored for too long after collection are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amyloid-beta 42;Amyloid-beta 40;Phosphorylated tau at threonine 181;Total tau protein;Neurofilament Light Chain;Glial Fibrillary Acidic Protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| mini-mental state examination,,MMSE;activities of daily life ,ADL;neuropsychiatric inventory, NPI;Clinical Dementia Rating Scale - Total Score,CDR-SB;Clinical Doctor Interview Supplementary Scale for Impression of Disease Changes,CIBIC-plus; | — |
Countries
China
Contacts
Public ContactShoukui Hu
Zhengzhou Central Hospital
Outcome results
None listed