stroke
Conditions
Interventions
Conventional TMS Group:Intermittent theta burst stimulation (iTBS) applied to the affected hemisphere's M1 area: It involves repetitive short trains of 50 Hz stimulation, with each train lasting for 2
DS-TMS:Intermittent theta burst stimulation (iTBS) is applied to the Supplementary Motor Area (SMA), consisting of repetitive short trains of 50 Hz stimulation, with each train lasting 2 seconds and a
TMS+BCI:Subjects first received BCI combined with upper limb robotic hand training therapy (30 minutes per session, 5 sessions per week), followed by DS-TMS treatment within 30 to 60 minutes thereafte
BCI+TMS:Subjects first received DS-TMS treatment, followed by BCI combined with upper limb robotic hand training therapy within 30 to 60 minutes thereafter.
Sponsors
China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 35-70 years old, with clear hand-to-hand records; 2. The duration of the first stroke is =24 points); 5. Stable vital signs, no serious diseases such as heart and lungs; 6. Intact scalp, no intracranial metal implants or pacemakers; 7. Study participants and caregivers sign the informed consent form, committing to complete >=80% of the intervention and examination; 8. Have the physical conditions to complete brain-computer interface training and neuroimaging examination (fNIRS/EEG/ERP).
Exclusion criteria
Exclusion criteria: 1. Upper limb pain or functional limitation on the affected side caused by other reasons, such as shoulder subluxation, shoulder-hand syndrome, cervical spinal cord injury, and peripheral neuropathy. 2. Pregnant or lactating women. 3. First stroke but the disease is still progressing. 4. Concomitant with severe neurological disease (such as epilepsy, Parkinson's disease, multiple sclerosis) or/and/or taking medications that alter cerebral cortical excitability. 5. Those who have serious mental illnesses (such as schizophrenia, bipolar disorder), visual field, speech, hearing dysfunction, tinnitus, etc., and cannot cooperate with assessment and treatment; 6. Combined with severe cardiopulmonary and other important organ insufficiency; 7. Received TMS, BCI or other neuromodulation therapy in the past 4 weeks; 8. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Fugl-Meyer Assessment, FMA); | — |
Countries
China
Contacts
Public ContactWu Xiaoli
Department of Neurorehabilitation, China Rehabilitation Research Center, China
Outcome results
None listed