skeletal muscle performance
Conditions
Interventions
Exercise group with probiotics:Probiotics taken twice daily for 12 weeks, the oral probiotics is Bifidobacterium animalis subsp. lactis MUS+
Exercise group with placebo:Placebo twice daily for 12 weeks, the placebo is maltodextrin, dose equivalent to probiotics
Sedentary group:Probiotics taken twice daily for 12 weeks, the oral probiotics is Bifidobacterium animalis subsp. lactis MUS+
Sponsors
Shandong Institute of Physical Education
Eligibility
Sex/Gender
All
Age
18 Years to 27 Years
Inclusion criteria
Inclusion criteria: 1. International Physical Activity Questionnaire (IPAQ): Exercise group (medium level): meet any of the following conditions: high intensity activity >=3 days/week and >=20 minutes/day; moderate intensity/walking activity >=5 days/week and >=30 minutes/day; total activity days =5 days/week and total physical activity >=600MET-min/week. Sedentary group (low level): no activity or activity does not meet the medium/high level criteria. 2. Sedentary group: total score of sedentary behavior questionnaire (SBQ) >=20. 3. Voluntary participation and signing of informed consent form.
Exclusion criteria
Exclusion criteria: 1. Use of various antifungal drugs, antibiotics, immunosuppressive drugs, antipsychotics (including ADHD drugs) and other probiotics, prebiotics, high-dose nutrients and other alternative therapies in the past month; 2. Severe diarrhea, constipation and other gastrointestinal diseases have occurred recently. 3. Other unstable or severe heart, lung, liver, kidney, hematopoietic system diseases (including unstable angina pectoris, uncontrollable asthma, severe allergies, active gastric bleeding, acute leukemia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skeletal muscle content; | — |
Secondary
| Measure | Time frame |
|---|---|
| anaerobic power of lower limb muscles;skeletal muscle endurance;skeletal muscle strength and Ultrasonic mechanical imaging of skeletal muscle;Determination of IL-6, IL-10 contents in the plasma;Determination of Myostatin, FGF21 contents in the plasma;Metagenomic analysis of the saliva samples;Metagenomic analysis of the fecal samples;Determination of short-chain fatty acids contents of the fecal samples; | — |
Countries
China
Contacts
Public ContactJibin Sha
Shandong Institute of Physical Education
Outcome results
None listed