Critical disorders of nervous system
Conditions
Interventions
Intervention group:Ultrasound-guided single botulinum toxin injection into the parotid and submandibular glands
Control group:Core airway prevention measures
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients with severe neuropathy aged >=18 years old; 2. NIHSS>=11 points, or GCS=48 hours; 4. The patient's family or legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Invasive mechanical ventilation support time = 24 hours at screening; 2. Novel coronavirus infection; 3. Extremely critical condition, vital sign fluctuations that cannot be stabilized by drugs and other treatments; 4. Severe bleeding tendency and coagulation mechanism disorders; 5. Serious and uncontrolled cardiopulmonary organic lesions before the onset of the disease, including pulmonary hypertension, moderate to severe heart failure, tuberculosis, lung infection, lung abscess, moderate/severe/very severe chronic obstructive pulmonary disease. 6. Those whose head and facial anatomical structures cannot be positioned by B-ultrasound due to structural disorders caused by past or existing medical history; 7. Those who have received head and neck radiotherapy or salivary gland surgery; 8. Those with an increased risk of infection due to past or existing medical history and treatment, including congenital/acquired immunodeficiency, long-term use of immunosuppressive drugs, post-organ transplantation, malignant tumors, and agranulocytosis; 9. Patients who have participated in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of ventilator-associated pneumonia; | — |
Countries
China
Contacts
Public ContactYi Li
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed