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Effect of Penehyclidine Combined with Flurbiprofen Axetil on Catheter-Related Bladder Discomfort after General Anesthesia

Effect of Penehyclidine Combined with Flurbiprofen Axetil on Catheter-Related Bladder Discomfort after General Anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107865
Enrollment
Unknown
Registered
2025-08-20
Start date
2025-08-20
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter-Related Bladder Discomfort

Interventions

C Group: Control Group:Intravenous normal saline (10 mL) was administered before anesthesia induction, followed by an additional 10 mL intravenous normal saline 15 minutes before the end of surgery.
PF Group: Combination Therapy Group:Penehyclidine (0.01 mg/kg diluted in 10 mL normal saline) was administered intravenously before anesthesia induction, followed by flurbiprofen axetil (100 mg IV) 30

Sponsors

Shandong Second Medical University Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-85 years old, ASA grade I-III; 2. TURP under general anesthesia is proposed; 3. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Severe cardiovascular disease, liver and kidney insufficiency; 2. There are drug contraindications 3. History of mental illness or gastric bleeding.

Design outcomes

Primary

MeasureTime frame
Catheter-Related Bladder Discomfort (CRBD) Severity Grading;—

Secondary

MeasureTime frame
VAS Pain Score;Ramsay Sedation Scale;—

Countries

China

Contacts

Public ContactZhang Chengming

Shandong Second Medical University Affiliated Hospital

zcm9318@163.com+86 133 7107 9139

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026