Postoperative nausea and vomiting after gynecological surgery
Conditions
Interventions
The teglitazone treatment group:Loading dose: 0.75 mg / 5 ml, administered by pump for 10 minutes
Maintenance: Prepared as 0.05 mg/ml, add 0.05 mg of dose with each press, add 1 ml of volume, and lock the dose for 10 minutes with each press.
The morphine treatment group:Loading dose: 3.0 mg / 5 ml, administered by pump for 10 minutes
Maintenance: Prepared as 1 mg/ml, add 1 mg of dose with each press, add 1 ml of volume, and lock the dose for 10 minutes with each press
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18 - 80 years old; 2.ASA classification: 1 - 3 grades; 3.Scheduled for elective gynecological laparoscopic surgery under general anesthesia; 4.Within 4 hours after the surgery, at any time, the resting NRS score was = 4 points; 5. Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to selective µ-receptor agonists or having taken such drugs within one week before the surgery; 2. Long-term use of long-acting antiemetic drugs, emetic drugs, opioid drugs or glucocorticoids, etc.; 3. Pregnant or lactating women; 4. Patients with developmental delay, mental disorders or severe neurological diseases; 5. Other diseases that may cause nausea and vomiting, such as hepatitis or gastric ulcers; 6. Refusal to participate in this clinical trial; 7. Allergic or having contraindications to the anesthetics, adjuvant analgesics, rescue analgesics, antiemetics, and antibiotics used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of nausea and vomiting 24 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The NRS score for pain 24 hours after the operation;Quality of recovery; | — |
Countries
China
Contacts
Public ContactXiaojie Liu
Affiliated Hospital of Qingdao University
Outcome results
None listed