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Exploring the pathogenesis of pediatric intussusception based on gut microbiota comparison: A Multicenter Retrospective and Prospective Cohort Study

Exploring the pathogenesis of pediatric intussusception based on gut microbiota comparison: A Multicenter Retrospective and Prospective Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500107853
Enrollment
Unknown
Registered
2025-08-20
Start date
2025-08-20
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric actue intussusception

Interventions

Intussusception group:None
Control group:None

Sponsors

Yijishan Hospital of Wannan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
0.3 Years to 5 Years

Inclusion criteria

Inclusion criteria: Case group: From August 2025 to December 2026, 6 hospitals including Yijishan Hospital of Wannan Medical College, Affiliated Hospital of Qingdao University, Qingdao Women and Children's Medical Center, Wuhan Children's Hospital, Hubei Maternal and Child Health Hospital, and Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital were selected to diagnose children with intussusception. The age range was set from 3 months to 36 months, and it is expected to include about 20 cases. Our center has about 10 cases (there have been 66 cases of intestinal microbiota sequencing data of children with intussusception in previous studies). Inclusion criteria: Clinical symptoms consistent with the presentation of intussusception, such as paroxysmal crying, vomiting, jam like bloody stools, etc., confirmed by ultrasound examination or air enema as intussusception, and no other complications such as severe congenital intestinal malformations. Control group: About 70 normal children who underwent physical examination in the pediatric health department of the hospital during the same period were matched with the case group in terms of age and gender.

Exclusion criteria

Exclusion criteria: Exclude children with digestive system diseases, recent use of antibiotics, or immune deficiencies that may affect gut microbiota.

Design outcomes

Primary

MeasureTime frame
Changes in abundance values of gut microbiota.;

Countries

China

Contacts

Public ContactLiu jie

Yijishan Hospital of Wannan Medical College

liujie19842020@163.com+86 139 6515 0287

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026