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Study on the clinical effect and mechanism of GnRH-a and HCG dual trigger inducing ovulation in patients with luteinized unruptured follicles

Study on the clinical effect and mechanism of GnRH-a and HCG dual trigger inducing ovulation in patients with luteinized unruptured follicles

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107824
Enrollment
Unknown
Registered
2025-08-19
Start date
2024-07-01
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

luteinized unruptured follicles syndrome

Interventions

Experimental Group:Double trigger when triggered
Control Group:HCG trigger when triggered

Sponsors

Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1.Women aged 20-38; 2.Patients who are planning to undergo OI/OI+IUI treatment; 3.Patients who meet the diagnostic criteria for LUFS and have received other treatments but have not achieved satisfactory results; 4.Patients who are willing to accept the treatment plan of this study and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1.Diagnosed uterine cavity abnormalities, including uterine malformation, uterine cavity adhesions, type 0-2 fibroids in accordance with FIGO uterine fibroid classification, or type 3-5 fibroids with a diameter greater than 5 cm, etc. 2.Patients with a history of tuberculosis or immune system diseases such as systemic lupus erythematosus; 3.Patients who have used NSAIDs for a long time or continuously for more than 3 months; 4.Ultrasound confirmed that there was hydrosalpinx and it was not treated; 5.After sperm washing, the husband has less than 10 million sperm with forward motility or the sperm morphology rate is less than 1%. 6.Exclude thyroid dysfunction, congenital adrenal hyperplasia, hypertension, diabetes, etc.

Design outcomes

Primary

MeasureTime frame
Ovulation rate;

Secondary

MeasureTime frame
Live birth rate;Pregnancy rate;

Countries

China

Contacts

Public ContactQin Huisi

Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region

35860169@qq.com+86 771 2860699

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026