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Clinical study of 18F-FAPI PET imaging in 90Y-SIRT of liver malignant tumors

Clinical study of 18F-FAPI PET imaging in the evaluation and prediction of 90Y-SIRT for liver malignant tumors

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500107817
Enrollment
Unknown
Registered
2025-08-19
Start date
2024-02-28
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver malignant tumors

Interventions

Case series:NA

Sponsors

The First Affiliated Hospital of Jinan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) unresectable primary or metastatic liver malignancy; (2) age >=18 years old; (3) ECOG =90g/L, absolute neutrophil count >1500/mm^3, platelet count >=80×10^9/L, ALT and AST<5 times the upper limit of normal value (ULN), total bilirubin <3×ULN, serum creatinine <1.5×ULN; Prothrombin time (PT) or international normalized ratio (INR), activated partial thromboplastin time (APTT) <1.5×ULN; (6) suitable for selective arterial cannulation and angiography.

Exclusion criteria

Exclusion criteria: Exclusion criteria: (1) Severe liver dysfunction, including severe jaundice, hepatic encephalopathy, refractory ascites or hepatorenal syndrome; (2) Child-Pugh grade C; (3) uncorrectable coagulation dysfunction; (4) renal dysfunction, liver creatinine >176.8u mol/L or creatinine clearance <30ml/min; (5) complicated with active hepatitis or infection; (6) diffuse or extensive distant metastasis; (7) abnormal vascular anatomy of the hepatic artery, or severe and uncorrectable hepatic artery-portal vein fistula or hepatic artery-hepatic vein shunt; (8) Portal vein tumor thrombus, embolism, less collateral vessel formation, and portal vein stent can not be used to recanalize the main portal vein to restore hepatic blood flow; (9) uncorrectable hepatic artery-gastrointestinal artery shunt; (10) severe contrast allergy; (11) the single lung absorbed dose exceeded 30Gy or the cumulative lung absorbed dose exceeded 50gy; (12) others: including pregnant women or lactating women.

Design outcomes

Primary

MeasureTime frame
SUVmax;SUVmean;SULmax;SULmean;Sensitivity;Specificity;

Countries

China

Contacts

Public ContactHao Xu, Mingrong Cao, Xueying Ling

The First Affiliated Hospital of Jinan University

txh@jnu.edu.cn+86 133 9269 2189

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 25, 2026