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The Impact of oliceridine on Postoperative Analgesic Effects and the Incidence of Nausea and Vomiting in Patients Undergoing Breast Cancer Surgery

The Impact of oliceridine on Postoperative Analgesic Effects and the Incidence of Nausea and Vomiting in Patients Undergoing Breast Cancer Surgery

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107815
Enrollment
Unknown
Registered
2025-08-19
Start date
2025-02-03
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer

Interventions

Group S:Sufentanil 3 µ g/kg was administered as a postoperative analgesic pump
Group O1:The postoperative analgesia pump was administered with oliceridine at a dose of 0.4mg/kg
Group O2:The postoperative analgesia pump was administered with oliceridine at a dose of 0.6mg/kg

Sponsors

Lu'an People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Female patients undergoing elective breast tumor surgery, the operation time is <=3h; 2. Age 40~65 years old; 3. ASA grade I.~II.; 4. Body mass index (BMI) <=30 kg/m^2; 5. After fully explaining the content of the clinical trial, voluntarily join and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Combined with serious diseases, such as abnormal liver and kidney function, abnormal lung function, severe cardiovascular and cerebrovascular diseases, etc.; 2. Those with poor control of diabetes and hypertension; Those who are suspected of having digestive system obstruction; 3. Those who have a history of motion sickness, severe nausea and vomiting, or use antiemetic drugs; 4. History of schizophrenia and other mental illnesses; Preoperative delirium or communication disorders.

Design outcomes

Primary

MeasureTime frame
The Visual Analog Scale (VAS) scores;Ramsay Sedation Scale scores ;Nausea and Vomiting;

Countries

China

Contacts

Public ContactXiaodong Peng

Lu'an People's Hospital

1784158909@qq.com+86 189 1970 1663

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026