Breast cancer
Conditions
Interventions
IMRT group:IMRT (chest wall + supraclavicular + internal mammary lymph node drainage area)
ALL-in-one group:ALL-in-one radiotherapy (chest wall + supraclavicular + internal mammary lymph node drainage area)
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 18-70 years; 2. ECOG 0-2 points; 3. Newly diagnosed invasive breast cancer, complete axillary lymph node dissection, axillary lymph node positive (ypN) surgical margin negative; 4. No distant metastasis; 5. Tolerate radiotherapy; 6. ER/PR positive patients receiving endocrine therapy for an expected 5 years; 7. HER2-positive patients receiving anti-HER2 targeted therapy for an expected 1 year; 8. Patients who require neoadjuvant/adjuvant therapy and need to complete chemotherapy; 9. LVEF 50% measured by cardiac echocardiography; 10. Adjuvant IMRT radiotherapy is required; 11. Lying still on the treatment bed of the tolerable treatment accelerator for 30 minutes, complete All-In-One one-stop radiotherapy; 12. Have the conditions for follow-up and are willing to insist on follow-up; 13. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Simultaneous bilateral breast cancer; axillary sentinel lymph node biopsy, no axillary dissection; 2. After stage I breast reconstruction or expander implantation of the chest wall on the affected side; 3. The purpose of radiotherapy is palliative radiotherapy; 4. Myocardial infarction or uncorrected unstable arrhythmia or uncorrected unstable angina in the past 3 months; 5. Previous history of chest wall or supraclavicular radiotherapy; Prior or concurrent second primary malignancy (except skin cancer, papillary/follicular carcinoma of the thyroid, carcinoma in situ of the cervix) of non-malignant melanoma; 6. All-in-one radiotherapy has not been completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence rate of adverse effects; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survical;Disease free survival;Cumulative internal mammary node recurrence;Cumulative locoregional recurrence;Distance metastasis;Contralateral non-invasive breast cancer, other secondary malignant tumors;Major cardiovascular events;Life quality; | — |
Countries
China
Contacts
Public ContactJiayuan Sun
Sun Yat-sen University Cancer Center
Outcome results
None listed