Advanced cancer
Conditions
Interventions
Test group:Ultrasound-guided Microwave Ablation combined with 125Iodine (125I) Particle Implantation
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Primary liver cancer: solitary tumor with diameter <=5 cm; or multiple tumors (number <=3) with the largest diameter <=3 cm. (2) Liver metastases: the primary lesion has been effectively controlled, with no extrahepatic metastases or stable extrahepatic metastatic foci, and intrahepatic lesions are expected to be completely ablated. (3) Superficial tumors: systemic superficial metastatic tumors or primary superficial tumors. (4) Palliative treatment for advanced tumors, aiming to maximally reduce tumor burden, alleviate tumor-related symptoms, improve patients' quality of life, and prolong survival.
Exclusion criteria
Exclusion criteria: (1) Diffuse tumor distribution. (2) Invasion of adjacent hollow organs. (3) Liver function Child-Pugh class C. (4) Uncorrectable coagulation dysfunction. (5) Concurrent active infection, especially biliary tract infection. (6) Refractory massive ascites or cachexia. (7) Failure of vital organs (heart, brain, lungs, kidneys). (8) ECOG performance status > grade 2. (9) Impaired consciousness or inability to cooperate with treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival;progress free survival;time to tumor progression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Symptom Improvement and Quality of Life Assessment;The comprehensive evaluation was conducted using the Quality of Life Assessment Scale combined with pain scores and performance status scores;Tumor Marker;Lymphocyte Subsets;TNF-a; | — |
Countries
China
Contacts
Public ContactChen Baoding
Affiliated Hospital of Jiangsu University
Outcome results
None listed