periapical periodontitis
Conditions
Interventions
periapical periodontitis:None
Control:None
Chronic periodontitis:None
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–70 years and indicated for tooth extraction on the basis of clinical examination; 2.Provision of written informed consent and a complete medical history; 3.Commitment to full trial participation, including attendance at all scheduled visits and completion of all study procedures; 4.Absence of systemic or topical antiviral therapy within the preceding 3 months; 5.Presence of >= 20 functional natural teeth; absence of rampant caries, active mucosal disease, acute oral inflammation, removable prostheses, or fixed/removable orthodontic appliances.
Exclusion criteria
Exclusion criteria: 1.Presence of severe systemic disease (as judged by the clinical investigator), including but not limited to cardiac arrhythmia, uncontrolled hypertension, diabetes mellitus, hepatitis of any etiology, or renal failure; 2.Pregnant or lactating women, or those planning pregnancy during the study period (self-reported); 3.History of head-and-neck radiotherapy or use of bisphosphonates, denosumab, or similar agents; 4.Current smoker (any form of tobacco use); 5.Periodontal therapy or antiviral medication within the preceding 3 months; 6.Any psychiatric disorder or other condition resulting in legally recognized diminished capacity to provide consent; 7.Lack of legal capacity to consent or refusal to participate; 8.Any additional condition that, in the opinion of the investigator, would preclude safe or compliant study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing Depth;Maximum diameter of apical lesion on X-ray; | — |
Countries
China
Contacts
Public ContactShen Yuqing
Zhongshan Hospital, Fudan University
Outcome results
None listed