Schizophrenia
Conditions
Interventions
HD-tDCS Treatment Group:High-Definition Transcranial Direct Current Stimulation (HD-tDCS)
Healthy control group:None
Sham Stimulation Group:Sham High-Definition Transcranial Direct Current Stimulation (Sham HD-tDCS)
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patient group:Meet the diagnostic criteria for schizophrenia according to the *Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); 2.Patient group:Aged 18-60 years, regardless of gender; 3.Patient group:PANSS score >= 60; 4.Patient group:Consent to combined treatment with high-definition transcranial direct current stimulation (HD-tDCS); 5.Patient group:Willing to participate in the study and sign the informed consent form; 6.Healthy control group:Aged 18-60 years, regardless of gender; 7.Healthy control group:Willing to participate in the study and sign the informed consent form; 8.Healthy control group:No history of mental illness, not taking any psychiatric medications; 9.Healthy control group:No history of neurological diseases including epilepsy, brain trauma, stroke, or neurodegenerative conditions; 10.Healthy control group:No severe cardiovascular, endocrine, immune system, or other somatic disorders that may affect cognitive function; 11.Healthy control group:Based on the Wechsler Adult Intelligence Scale (WAIS) assessment, the IQ score was >= 90, indicating no cognitive dysfunction;
Exclusion criteria
Exclusion criteria: 1.Patient group:Severe agitation/impulsivity and self-harm/suicidal tendencies; 2.Patient group:Contraindications to treatment (e.g., intracranial metal implants); 3.Patient group:History of electroconvulsive therapy within the past month; 4.Patient group:Pregnancy; 5.Patient group:History of alcohol or other psychoactive substance abuse; severe physical illness; 6.Patient group:Intellectual impairment (IQ < 90); 7.Healthy control group:Family history of mental disorders (in first-degree relatives); 8.Healthy control group:Presence of severe sleep disorders, hearing or visual impairments that may affect cognitive test results; 9.Healthy control group:History of electroconvulsive therapy within the past month; 10.Healthy control group:Pregnancy; 11.Healthy control group:History of alcohol or other psychoactive substance abuse; severe physical illness; 12.Healthy control group:Intellectual impairment (IQ < 90);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RBANS;PANSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| TMS-EEG cortical reactivity (TEP amplitude);PSP; | — |
Countries
China
Contacts
Public ContactChen Zan
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed