Sedation during cesarean section
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine nasal spray ( 25 µg / spray × 4 spray, total 100 µg ) was injected immediately after umbilical cord clamping. Operation specification : maternal head back 45 °, b
Saline group:Nasal spray of the same amount of normal saline after umbilical cord amputation (appearance and operation procedure are consistent with the intervention group)
Sponsors
Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine/ Affiliated Hospital of Panzhihua University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Singleton full-term ( >=37 weeks ) parturients undergoing elective cesarean section under spinal / epidural anesthesia ; 2.ASA grade I-II ; 3.18-40 years old, BMI 18-30 kg / m^2 ; 4.Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1.Emergency surgery : patients with severe pregnancy complications such as acute fetal distress, eclampsia, and placenta previa ; 2.Developmental abnormalities such as fetal congenital malformations ; 3.Diseases such as nasal structural abnormalities or recent history of nasal surgery ; 4.With bradycardia ( HR < 60 beats / min ), hypotension ( SBP < 90 mmHg ) or severe cardiopulmonary disease ; 5.Dexmedetomidine allergy history ; 6.History of mental illness ; 7.General anesthesia patients with spinal anesthesia contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation scale;Oxygen saturation;Heart rate;Blood pressure;1-minute Apgar score;Whether endotracheal intubation is required;Neonatal Neurological Score;Sedative dosage;The first effective sucking time and the number of lactations within 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postpartum depression score ( EPDS scale );Shivering;The first postoperative exhaust time;Nausea and vomiting; | — |
Countries
China
Contacts
Public ContactFeng Zhu
Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine/ Affiliated Hospital of Panzhihua University
Outcome results
None listed