Postpartum Depression and Pain
Conditions
Interventions
Test group:Intravenous esketamine
Control group:After the fetus is delivered, dexmedetomidine is administered by pump.
Sponsors
Wenzhou People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Parturients undergoing cesarean delivery under neuraxial anesthesia; 2. Aged >=18 years; 3. ASA II level; 4. Gestation >=28 weeks; 5. Require postoperative intravenous patient-controlled analgesia; 6. Preoperative Pittsburgh Sleep Quality Index (PSQI) >=7; 7. The parturient can communicate effectively with the interviewer, understands the trial process, and voluntarily participates in this study and signs the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of mental illness or depression in the past; 2. Severe cardiovascular and cerebrovascular diseases and liver and kidney insufficiency; 3. Have a history of psychotropic drugs and alcohol abuse; 4. Severe eclampsia; 5. Allergy to the drugs in this trial; 6. Placenta previa, placental abruption and other diseases with estimated blood loss greater than 800 ml before surgery; 7. Preoperative sinus bradycardia (maternal heart rate less than 50 beats/min), or abnormal heart conduction or heart rhythm diseases such as sick sinus syndrome; 8. Preoperative hypotension (standard systolic blood pressure less than 90mmHg and/or diastolic blood pressure less than 60mmHg); 9. Unable to understand the language of the follow-up and communicate well.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postpartum depression on the seventh day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remedial analgesic medication situation;Postoperative VAS score;Incidence of self harming thoughts;Remedial analgesic medication situation; | — |
Countries
China
Contacts
Public ContactJing Chen
Wenzhou People's Hospital
Outcome results
None listed