Ventilator-Associated Pneumonia
Conditions
Interventions
phage therapy group:Phage cocktail administered via nebulization
control group:Nebulized normal saline inhalation therapy
Sponsors
College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with ventilator-associated pneumonia (VAP); 2. Identified infection with MDR Klebsiella pneumoniae, Acinetobacter baumannii, or Pseudomonas aeruginosa via MROSE evaluation and antimicrobial susceptibility testing (AST) from this or other tertiary hospitals; 3. Aged 18 to 85 years; 4. Written informed consent obtained from the patient or legal guardian.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women; 2. FiO2 >= 70% or PEEP >= 15 cmH2O; 3. Hemodynamic instability (vasopressor dose increased by >=30% in the last 6 hours or norepinephrine > 0.5 µg/kg/min); 4. Known allergy to phage components.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bacterial clearance rate;28 day all-cause mortality rate;clinical pulmonary infection score;length of hospital stay;Invasive mechanical ventilation time; | — |
Countries
China
Contacts
Public ContactWeihua Zhang
Chinese PLA General Hospital Eighth Medical Center
Outcome results
None listed