Postoperative nausea and vomiting
Conditions
Interventions
Esomeprazole group:30 minutes before anesthesia induction, 40mg of esomeprazole was administered intravenously for 3 minutes (add 1 bottle of 40mg of esomeprazole freeze-dried powder to 5mL of normal
Control group :Give 5ml of normal saline by intravenous injection for 3 minutes 30 minutes before anesthesia induction.
Sponsors
Department of anesthesiology, the First Affilitated hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old; 2. BMI: 18-30 kg/m²; 3. ASA I-III grade; 4. Female patients who plan to undergo elective thyroidectomy under general anesthesia; 5. History of motion sickness or PONV; 6. No gastrointestinal diseases, and no gastrointestinal surgeries have been performed except for simple cholecystectomy; 7. Communication and interaction are normal; 8. Take the test voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to esomeprazole; 2. Take antiemetic or analgesic drugs within 24 hours before the operation; 3. Use H2 receptor inhibitors and PPIs; 4. Use drugs that interact with esomeprazole (such as phenytoin, diazepam, ketoconazole, itraconazole, warfarin/vitamin K antagonists, clopidogrel, etc.); 5. Use of antipsychotic drugs or corticosteroid drugs; 6. Previous heart failure or arrhythmia; Uncontrolled hypertension Diabetes mellitus with poor blood sugar control; Liver and kidney dysfunction; Gastric motility disorder Vestibular disorders; 7. Pregnant or lactating women; 8. Inability to understand the Postoperative Quality of Recovery Scale (QoR-15)/Visual Analogue Scale (VAS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale pain score ;Ramsay sedation score ;PONV impact scale;Quality of recovery-15 items;Incidence of nausea and vomiting 1 hour and 6 hours after surgery;Use of remedial antiemetics and remedial analgesics;PACU residence time;time of first exhaust;time of first defecation;hospital stays;Whether opioid drugs are used after the operation;The number of users and dosage of vasoactive drugs;The number of users and dosage of neostigmine; | — |
Countries
China
Contacts
Public ContactLu Yao
Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University
Outcome results
None listed