Lumbar spinal stenosis, lumbar disc herniation
Conditions
Interventions
Propofol group (group P):(1) Induction of anesthesia: in group P, anesthesia was induced with propofol 1.5 mg/kg, sufentanil 0.3µg/kg and rocuronium 0.6 mg/kg. (2) Anesthesia maintenance: In group P,
(C):(1) Induction of anesthesia: in group C, anesthesia was induced with ciprofol 1.5 mg/kg, sufentanil 0.3µg/kg and rocuronium 0.6 mg/kg. (2) Anesthesia maintenance: In group C, ciprofol 2.5-7.5 mg·k
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Men and women are not limited; 2. Age 65-85 years old; 3. 18 kg/m2 < BMI < 28 kg/m2; 4. American Society of Anesthesiologists (ASA) grade I-III; 5. Patients undergoing posterior lumbar fusion under general anesthesia with endotracheal intubation; 6. Consent to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of cardiovascular disease including severe hypertension (systolic blood pressure >=180 mmHg), unstable angina pectoris, severe arrhythmia, and cardiac insufficiency; 2. Patients were complicated with endocrine diseases and severe liver and renal dysfunction before operation; 3. Respiratory failure (PaO2<60mmHg); 4. The history of stroke was less than 3 months; 5. Patients were allergic to cyclopropofol, propofol and other drugs and their drug components; 6. Patients with a previous history of mental illness or dementia who were unable to cooperate with the completion of the study; 7. Patients who planned to undergo surgery for 4 or more spinal segments; 8. The patient and family members declined to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score;The occurrence of intraoperative adverse events;The use of vasoactive drugs during operation;Intraoperative consumption of ciprofol;Intraoperative consumption of propofol;Intraoperative consumption of remifentanil ;Intraoperative consumption of sufentanil;Recovery time ;Extubation time;RASS score;Blood Glucose Level;The occurrence of postoperative complications;Postoperative HOSPITAL STAY;Postoperative first flatus time;Postoperative first defecation time;Postoperative NRS pain scores at rest and during activity (cough); | — |
Countries
China
Contacts
Public ContactMa Yanhui
Xuanwu Hospital, Capital Medical University
Outcome results
None listed