major abdominal surgery
Conditions
Interventions
Cyclopofol group:Anesthesia was induced and maintained with cyclopropofol
Propofol group:Anesthesia was induced and maintained with propofol
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >65 years old, BMI value 18-30m^2/kg; 2. American society of anesthesiology (ASA) grade I~III; 3. CAM confirmed that there was no pre-existing delirium before surgery; 4. The score of the Mini-Mental State Examination Scale >=15 points.
Exclusion criteria
Exclusion criteria: 1. History of previous neurological or psychiatric diseases; 2. Long-term use of sedative, hypnotic and antipsychotic drugs; 3. Severe vision and hearing impairment; 4. BMI value less than 18 m^2/kg or greater than 30 m^2/kg; 5. Those who have dysfunction of important organs such as heart, lung, liver, and kidney.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and duration of POD (within 7 days after surgery); | — |
Secondary
| Measure | Time frame |
|---|---|
| Record the unit time dosage of propofol, propofol, and remifentanil during anesthesia maintenance, as well as the use of related drugs (atropine, methoxamine, norepinephrine, dopamine) during surgery;Quality of awakening;hemodynamics;SII value; | — |
Countries
China
Contacts
Public ContactYujiao Yang
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed