Major depressive disorder
Conditions
Interventions
Anhedonia group:a-iTBS intervention with 10 times a day
Non-anhedonia group:Receive routine clinical treatment without clinical intervention, and only baseline measurements are conducted.
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age: 12-18 years old, gender not limited. 2.The subjects are determined by psychiatrists to meet the diagnostic criteria For depressive disorder episodes in DSM-5. 3.17-item Hamilton Rating Scale For Depression (HAMD-17) score >=17 points; 4.Capable of completing the assessment; 5.Right-handed; 6.Normal vision; 7.Signed informed consent form by the individual and their family members.
Exclusion criteria
Exclusion criteria: 1. Meet the diagnostic criteria for other mental disorders in DSM-5; 2. Suffering from serious physical diseases; 3. Severe suicidal ideation or behavior; 4. The score of the Concise Merriam-Webster Children's Intelligence Test (under 16 years old) or the Brief Webster Adult Intelligence Test (over 16 years old) is <70; 5. Suffering from claustrophobia or other contraindications to magnetic resonance; 6. Patients with anhedonia have contraindications to TMS;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores on anhedonia-related scales; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychological related to cognitive behavior;Imaging indicators;Scores of other clinical symptom-related scales; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed