Visceral traction pain
Conditions
Interventions
C group:The dose of esketamine is 0.35mg/kg
B group:The dose of esketamine is 0.25mg/kg
D group:The dose of esketamine is 0.45mg/kg
A group:The dose of esketamine is 0.15mg/kg
Sponsors
Hangzhou Women's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. ASA Level I-II; 3. Elective full-term cesarean section; 4. Body mass index (BMI) 18-30 kg/m^2; 5. Signed informed consent, able to accept experimental methods, and voluntarily serve as test subjects.
Exclusion criteria
Exclusion criteria: 1.Those with contraindications to combined spinal-epidural anesthesia; 2.Those with abnormal blood coagulation or hematopoietic function; 3.Patients with adrenal cortical insufficiency; 4.Patients with contraindications to esketamine (such as glaucoma and large vessel aneurysms); 5.Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure exceeding 180/110 mmHg (note)); 6.Patients with severe cardio-pulmonary, hepatic or renal dysfunction, diabetes mellitus and other metabolic diseases, those who have been using glucocorticoids for a long time, those with a history of drug or alcohol abuse, or those with mental illnesses; 7.Emergency surgery; 8.Investigators who disagree to participate or are participating in other drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visceral traction reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Hemodynamic changes;MOAA/S score;Neonatal APGAR Score;Adverse reactions;Neonatal outcomes;Waking time; | — |
Countries
China
Contacts
Public ContactZhenfeng Zhou
Hangzhou Women's Hospital
Outcome results
None listed