Effect of preemptive analgesia with bromelain on postoperative pain after mandibular third molar extraction: a randomized controlled trial
Conditions
Interventions
Group bromelain:Preemptive analgesia with bromelain orally
Group placebo:Pre-treatment with oral placebo
Sponsors
Quanzhou Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Adult individuals aged 18 to 35 years, of any gender and ethnicity; 2. Good overall health (classified as ASA I and II by the American Society of Anesthesiologists) ; 3. No extraction contraindications; non-menstruating and non-lactating females; 4. Having both lower third molars, right and left, partially or fully impacted, with similar positioning and root formation, showing healthiness and indication for extraction; 5. Having no allergies to the pharmacological substances used in the study or their components and not to be taking other medications known to interact with bromelain; 6. Informed consent was obtained from all participants.
Exclusion criteria
Exclusion criteria: 1. Presence of pathological lesions associated with lower third molars; 2. Acute pericoronitis; 3. Recent history of chemotherapy and/or radiotherapy in the head and neck region, smoking, pregnancy, or lactation; 4. Classified as ASA III and IV by the American Society of Anesthesiologists; 5. Presence of renal or hepatic insufficiency; 6. Having allergies to the pharmacological substances used in the study or their components and be taking other medications known to interact with bromelain; 7. Surgery duration exceeding 40 min, difference in operative times exceeding 10 min; 8. Development of postoperative infection; 9. Failure to attend scheduled postoperative follow-up appointments, voluntary withdrawal during the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygen saturation;Blood pressure;Heart rate;BMI;Facial swelling;Maximal interincisal opening;The use of additional analgesic medication; | — |
Countries
China
Contacts
Public ContactHu Mingying
Quanzhou Medical College
Outcome results
None listed