depressive disorder
Conditions
Interventions
Experimental group:Aripiprazole
Control group:Minoxidil combined with placebo treatment
Sponsors
Jingzhou mental health center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18~65 years old; 2. Meet the ICD-10 diagnostic criteria for moderate/major depressive disorder, independently diagnosed by 2 psychiatrists with intermediate titles or above; 3. Hamilton Depression Rating Scale 17 items (HAMD-17) score >17 points; 4. Primary school education or above, able to cooperate with examination and diagnosis and treatment; 5. Right-handed; 6. Patients or family members give informed consent to this study.
Exclusion criteria
Exclusion criteria: 1. Exclude those with brain organic diseases, epilepsy and other neurological history, brain trauma or surgery; 2. Those with various serious physical diseases such as severe cardiopulmonary, hypertension, liver and kidney insufficiency and poorly controlled diabetes; 3. Clearly diagnosed schizophrenia, bipolar disorder and other mental disorders; 4. Those with psychotic symptoms such as hallucinations, delusions or depressive stiffness; 5. Those who have self-injury or suicidal behavior; 6. Those who have a history of drug and alcohol abuse; 7. Women who are pregnant, lactating and preparing for pregnancy; 8. Allergic to milnacipran or aripiprazole.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of Hamilton Depression Rating Scale (HAMD-17);The reduction rate of the HAMD-17 scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| The ISI scale was used for assessment separately. The higher the total score, the more obvious the insomnia condition was;Evaluation of drug side effects;Each subject underwent the HAMA assessment. The higher the total score, the more obvious the anxiety state was;Blood routine test, liver and kidney function test, electrolyte test, blood sugar and lipid test, electrocardiogram test;The higher the total score of WCPA is, the more obvious the clinical physical symptoms tend to be;Assessment of the degree of suicidal ideation; | — |
Countries
China
Contacts
Public ContactJunfeng Xu
Jingzhou Mental Health Center
Outcome results
None listed