Compensated hepatitis B liver cirrhosis
Conditions
Interventions
CHESS-SAVE graded treatment group(low risk):None
CHESS-SAVE graded treatment group(medium risk):None
CHESS-SAVE graded treatment group(high risk):None
Control Group:None
Sponsors
Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 65 years old; 2. Diagnosed with compensated hepatitis B liver cirrhosis; 3. Undergoing antiviral treatment for hepatitis B, using the first-line antiviral drugs recommended in the "Chinese Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition)"; 4.The patient is able to understand and voluntarily signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Has contraindications for electronic gastroscopy; 2. Platelet count 9; 6. Has experienced decompensation events (ascites, gastrointestinal bleeding, and hepatic encephalopathy) in the past; 7. Has viral hepatitis other than hepatitis B, such as hepatitis A, hepatitis C, hepatitis D, hepatitis E, and HIV infection; 8. Has been diagnosed with liver cancer; 9. Has undergone splenectomy or congenital absence of the spleen in the past; 10. Gastroscopy indicates high-risk esophageal and gastric varices; 11. Has contraindications for interferon treatment; 12.Insufficient clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of decompensated liver cirrhosis events;The mortality rate associated with decompensated liver cirrhosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Deaths caused by other factors;HCC incidence;Change in liver stiffness;Change in spleen hardness;The changes in the degree of gastric esophageal varices; | — |
Countries
China
Contacts
Public ContactQun Zhang ; Xiaolong Qi
Zhongda Hospital, Southeast University
Outcome results
None listed