Skip to content

Research on the Mechanism of Action of Accelerated iTBS (aiTBS) in Regulating Glu/GABAergic Neural E/I Balance on Anhedonic Depression

Research on the Mechanism of Action of Accelerated iTBS (aiTBS) in Regulating Glu/GABAergic Neural E/I Balance on Anhedonic Depression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107572
Enrollment
Unknown
Registered
2025-08-14
Start date
2025-08-19
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depressive symptoms

Interventions

Sponsors

Affiliated Kangning Hospital of Ningbo University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Meeting the diagnostic criteria for depression as stipulated in the Diagnostic and Statistical Manual of Mental Disorders (5th Edition); 2.(2) Age 16 to 60 years old; 3.(3) Hamilton Depression Rating Scale 24-item score = 20 points; 4.(4) Snaith-Hamilton Pleasure Scale (SHAPS) score = 28 points; 5.(5) Right-handed; 6.(6) Those who signed the informed consent form; 7.(7) Taking stable antidepressants and not changing the medication during the intervention period.

Exclusion criteria

Exclusion criteria: 1. Patients with severe somatic diseases, infectious diseases and immune system diseases; 2.(2) Patients with severe neurological diseases, mental retardation or organic brain diseases; 3.(3) Pregnant or lactating women; 4.(4) Those who have received electroconvulsive therapy within the last three months; 5.(5) Those with a history of epileptic seizures; 6.(6) Those who have participated in previous or current other research projects, such as tDCS, tACS or other neurostimulation treatments; 7.(7) Those with implanted metal pacemakers, cardiovascular stents placed in the body, or DBS electrodes placed in the brain, etc.

Design outcomes

Primary

MeasureTime frame
Clinical scale;

Secondary

MeasureTime frame
Electromyography;Brain region activation, functional connectivity, etc;

Countries

China

Contacts

Public ContactLi Xingxing

Affiliated Kangning Hospital of Ningbo University

290534201@qq.com+86 138 5747 6641

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026