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Effect of epidural volume expansion with physiological saline on 50% effective dose of isospecific gravity bupivacaine for subarachnoid block in patients undergoing varicose veins surgery

Effect of epidural volume expansion with physiological saline on 50% effective dose of isospecific gravity bupivacaine for subarachnoid block in patients undergoing varicose veins surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107569
Enrollment
Unknown
Registered
2025-08-14
Start date
2025-08-25
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicose veins in the lower extremities

Interventions

E5 Group:Epidural injection of 5 mL of normal saline
E10 group:Epidural injection of 10 mL of normal saline
C Group:No fluid is given to the epidural

Sponsors

Affliated Hospital of NorthSichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. ASA grade I.-III; 2. Patients who underwent elective lower limb varicose vein surgery; 3. Age 18-65 years old, gender is not limited; 4.BMI 18.5-27.9kg/m^2; 5. No contraindications to neuraxial anesthesia; 6. Those who sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Those with liver and kidney insufficiency; 2. Patients with lower limb movement, hearing dysfunction and mental system diseases; 3. Congenital anatomical abnormalities.

Design outcomes

Primary

MeasureTime frame
Isospecific gravity bupivacaine for ED50 of subarachnoid block in patients undergoing varicose vein surgery of the lower extremities;

Secondary

MeasureTime frame
Sensory block onset time;Duration of sensory block;Motor block onset time;Duration of motor block;Hemodynamics;The Anesthesia Satisfaction Rating Scale (ISAS) was used to evaluate the patients' postoperative anesthesia satisfaction;Anesthesia plane and analgesia time;Adverse reactions;

Countries

China

Contacts

Public ContactWang Ji

Affliated Hospital of NorthSichuan Medical College

wangjinsmc@sina.com+86 135 6861 2696

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026